The course of a disease can lead to either formation or loss of organic compounds in metabolism as well as changes within the biological matrix. The advantages of the IR analytical method are that it is based on a direct, non-destructive measurement of sample material and that the resulting IR spectra provide extensive and specific information about the sample composition and structure. Microscopic examination methods usually involve sampling followed by a method of sample purification or preparation. Due to a number of recent technological developments advances have been made in IR microscopy and in particular, rapid detection methods. The use of microscopy is a valuable means of gaining vital information for medical diagnostics. In order to achieve early diagnosis, a comprehensive cancer education program should be planned and executed, and proper screening programs should be launched. Some malignant lesions showed early presentation as compared to United States of America, with 6.9% cases presenting at a young age and 23.6% of cases presented at middle age. Colorectal carcinoma showed frequent presentation in our population. In our study 21% of patients presented in their 3rd decade of life, 18.4% in the 4th decade, 15.8% in the 5th decade, 26.3% in the 6th decade, 10.5% in the 7th decade and 7.9% in the 8th decade. Among these cases there were 31 cases (81%, mean age 56) of colorectal adenocarcinoma, 3 cases (7.6%, mean age 35) of signet cell carcinoma, 2 cases (5%, mean age 55.5) of mucinous adenocarcinoma, one case (2.5%, age 68) of metastatic papillary carcinoma, one case of mixed mucin secreting signet cell carcinoma (2.5%, age 64) and one case (2.5%, age 55) of poorly differentiated squamous cell carcinoma. We found 39 cases (21 males and 17 females) of colorectal cancer during this period, which constituted 1.5% of total endoscopic biopsies and 13.8% of colorectal biopsies. We received 2552 gastrointestinal endoscopic specimens during a 4 year period out of these 276 were colorectal specimens. The histopathological characteristics of the tumor such as tumor differentiation, tumor Duke's staging and grade of all the tumors were studied and compared with age of the patients.
Our study group consisted of 39 colorectal cancer patients, who were examined, over a period of 4 years from January 1996 to December 2000.
The aim of this retrospective study is to delineate the histopathological profile of colorectal cancers and to compare our findings with 12 other studies published in the literature from other areas.
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